Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference

• Main Authors: Masaki Takahashi (Author), Mari Suzuki (Author), Masashi Fukuoka (Author), Nobuhiro Fujikake (Author), Shoko Watanabe (Author), Miho Murata (Author), Keiji Wada (Author), Yoshitaka Nagai (Author), Hirohiko Hohjoh (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The α-synuclein (SNCA) gene is a responsible gene for Parkinson's disease (PD); and not only nucleotide variations but also overexpression of SNCA appears to be involved in the pathogenesis of PD. A specific inhibition against mutant SNCA genes carrying nucleotide variations may be feasible by...