Formulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system

• Auteurs principaux: Hetal Thakkar (Auteur), Jitesh Nangesh (Auteur), Mayur Parmar (Auteur), Divyakant Patel (Auteur)
• Format: Livre
• Publié: Wolters Kluwer Medknow Publications, 2011-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background : Raloxifene, a second-generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women is administered orally in the form of a tablet. The absolute bioavailability of the drug is only 2% because of extensive hepatic first-pass metabolism. Lipid...