Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

• Main Authors: Gundala Venkata Naveen Kumar (Author), Keito Hoshitsuki (Author), Sanjay Rathod (Author), Manda J. Ramsey (Author), Lauren Kokai (Author), Erin E. Kershaw (Author), Wen Xie (Author), Christian A. Fernandez (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis, with obesity and older age considered risk factors of the injury. Our study aim...