Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation

• Main Authors: Alessandra Menon (Author), Pasquale Creo (Author), Marco Piccoli (Author), Sonia Bergante (Author), Erika Conforti (Author), Giuseppe Banfi (Author), Pietro Randelli (Author), Luigi Anastasia (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adult stem cell-based therapeutic approaches for tissue regeneration have been proposed for several years. However, adult stem cells are usually limited in number and difficult to be expanded in vitro, and they usually tend to quickly lose their potency with passages, as they differentiate and becom...