Identification of new allosteric sites and modulators of AChE through computational and experimental tools

• Main Authors: Carlos Roca (Author), Carlos Requena (Author), Víctor Sebastián-Pérez (Author), Sony Malhotra (Author), Chris Radoux (Author), Concepción Pérez (Author), Ana Martinez (Author), Juan Antonio Páez (Author), Tom L. Blundell (Author), Nuria E. Campillo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for am...