Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening

• Главные авторы: Huizhen Ge (Автор), Lizeng Peng (Автор), Zhou Sun (Автор), Huanxiang Liu (Автор), Yulin Shen (Автор), Xiaojun Yao (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Hematopoietic progenitor kinase (HPK1) is a negative regulator of T-cell receptor and B-cell signaling, which has been recognized as a novel antitumor target for immunotherapy. In this work, Glide docking-based virtual screening and kinase inhibition assay were performed to identify novel HPK1 inhib...