Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling

• Main Authors: Yong Rao (Author), Rui Su (Author), Chenyan Wu (Author), Xingxing Chai (Author), Jinjian Li (Author), Guanyu Yang (Author), Junjie Wu (Author), Tingting Fu (Author), Zhongping Jiang (Author), Zhikai Guo (Author), Congjun Xu (Author), Ling Huang (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease (MAFLD). However, there are few reported lipotoxicity inhibitors. Here, we identified a natural anti-lipotoxicity candidate, HN-001, from the ma...