Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling

• Үндсэн зохиолчид: Yong Rao (Зохиогч), Rui Su (Зохиогч), Chenyan Wu (Зохиогч), Xingxing Chai (Зохиогч), Jinjian Li (Зохиогч), Guanyu Yang (Зохиогч), Junjie Wu (Зохиогч), Tingting Fu (Зохиогч), Zhongping Jiang (Зохиогч), Zhikai Guo (Зохиогч), Congjun Xu (Зохиогч), Ling Huang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2024-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease (MAFLD). However, there are few reported lipotoxicity inhibitors. Here, we identified a natural anti-lipotoxicity candidate, HN-001, from the ma...