Apamin structure and pharmacology revisited

• Main Authors: Alexey I. Kuzmenkov (Author), Steve Peigneur (Author), Joshua A. Nasburg (Author), Konstantin S. Mineev (Author), Maxim V. Nikolaev (Author), Ernesto Lopes Pinheiro-Junior (Author), Alexander S. Arseniev (Author), Heike Wulff (Author), Jan Tytgat (Author), Alexander A. Vassilevski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial. Here, we investigated the molecular pharmacology of apamin by two-electrode voltage-clamp...