New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis

• প্রধান লেখক: Hiromi Sato (লেখক), Ryota Yamada (লেখক), Midori Yanagihara (লেখক), Hiroko Okuzawa (লেখক), Hiroki Iwata (লেখক), Ayako Kurosawa (লেখক), Saki Ichinomiya (লেখক), Rina Suzuki (লেখক), Hiroyuki Okabe (লেখক), Tomohiro Yano (লেখক), Takuya Kumamoto (লেখক), Noriyuki Suzuki (লেখক), Tsutomu Ishikawa (লেখক), Koichi Ueno (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2012-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In this study, we describe the antitumor activity of QO-1, one of the new 2-aryl-1,4-naphthoquinone-1-oxime methyl ether derivatives. QO-1 is a derivative of macarpine, a natural occurring product from Rutaceae plant. It could potently inhibit cell growth when tested on 19 cancer cell lines. To inve...