New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis

• Main Authors: Hiromi Sato (Author), Ryota Yamada (Author), Midori Yanagihara (Author), Hiroko Okuzawa (Author), Hiroki Iwata (Author), Ayako Kurosawa (Author), Saki Ichinomiya (Author), Rina Suzuki (Author), Hiroyuki Okabe (Author), Tomohiro Yano (Author), Takuya Kumamoto (Author), Noriyuki Suzuki (Author), Tsutomu Ishikawa (Author), Koichi Ueno (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we describe the antitumor activity of QO-1, one of the new 2-aryl-1,4-naphthoquinone-1-oxime methyl ether derivatives. QO-1 is a derivative of macarpine, a natural occurring product from Rutaceae plant. It could potently inhibit cell growth when tested on 19 cancer cell lines. To inve...