First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation

First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation

Abstract Background The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC), owing to their well documented phagocytosis-driven mechanism of immuno...

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Main Authors: Fyyaz Siddiqui (Author), Denis Gallagher (Author), Hannah Shuster-Hyman (Author), Lianet Lopez (Author), Andrée Gauthier-Fisher (Author), Clifford L Librach (Author)
Format: Book
Published: BMC, 2023-05-01T00:00:00Z.
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