Evidence for the Role of the Mitochondrial ABC Transporter MDL1 in the Uptake of Clozapine and Related Molecules into the Yeast <i>Saccharomyces cerevisiae</i>

• Main Authors: Chrispian W. Theron (Author), J. Enrique Salcedo-Sora (Author), Justine M. Grixti (Author), Iben Møller-Hansen (Author), Irina Borodina (Author), Douglas B. Kell (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clozapine is an antipsychotic drug whose accumulation in white cells can sometimes prove toxic; understanding the transporters and alleles responsible is thus highly desirable. We used a strategy in which a yeast (<i>Saccharomyces cerevisiae</i>) CRISPR-Cas9 knock-out library was exposed...