Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology

• Main Authors: Stanley M. Walls (Author), Dale A. Chatfield (Author), Karen Ocorr (Author), Greg L. Harris (Author), Rolf Bodmer (Author)
• Format: Knjiga
• Izdano: The Company of Biologists, 2020-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems have shown the inhibition of ceramide biosynthesis to antagonize obesity and improve insulin sensitivity. Sphingosine Δ4 desaturase (encoded by...