Physiologically based modeling reveals different risk of respiratory depression after fentanyl overdose between adults and children

• Main Authors: Shilpa Chakravartula (Author), Bradlee Thrasher (Author), John Mann (Author), Anik Chaturbedi (Author), Xiaomei Han (Author), Albert Dahan (Author), Jeffry Florian (Author), David Strauss (Author), Zhihua Li (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Despite a rapid increase in pediatric mortality rate from prescription and illicit opioids, there is limited research on the dose‐dependent impact of opioids on respiratory depression in children, the leading cause of opioid‐associated death. In this article, we extend a previously develope...