Template Entrance Channel as Possible Allosteric Inhibition and Resistance Site for Quinolines Tricyclic Derivatives in RNA Dependent RNA Polymerase of Bovine Viral Diarrhea Virus

• Автори: Mitul Srivastava (Автор), Lovika Mittal (Автор), Debapriyo Sarmadhikari (Автор), Vijay Kumar Singh (Автор), Antonella Fais (Автор), Amit Kumar (Автор), Shailendra Asthana (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The development of potent non-nucleoside inhibitors (NNIs) could be an alternate strategy to combating infectious bovine viral diarrhea virus (BVDV), other than the traditional vaccination. RNA-dependent RNA polymerase (RdRp) is an essential enzyme for viral replication; therefore, it is one of the...