Clostridium difficile suppresses colonic vasoactive intestinal peptide associated with altered motility

• Main Authors: A. Nassif (Author), W. E. Longo (Author), R. Sexe (Author), M. Stratton (Author), J. Standeven (Author), A. M. Vernava (Author), D. L. Kaminski (Author)
• Format: Book
• Published: Hindawi Limited, 1995-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated whether Clostridium difficile toxin alters colonic tissue levels of vasoactive intestinal peptide (VIP) at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 10−8 M C. difflcile...