Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension

• Main Authors: Pei Qian (Author), Qian Wang (Author), Fang-Zheng Wang (Author), Hang-Bing Dai (Author), Hong-Yu Wang (Author), Qing Gao (Author), Hong Zhou (Author), Ye-Bo Zhou (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to determine whether adrenomedullin (ADM, 7.2 μg/kg/day, ip), an important endogenous active peptide, has a protective role in cardiac remodeling and function in obesity-related hypertension (OH) rats. A high-fat diet (HFD) was used to induce OH for 20 weeks. H9c2 cells incubated wi...