Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability

• Main Authors: Ce Yi (Author), Fei Xie (Author), Xin Xu (Author), Dian Xiao (Author), Xinbo Zhou (Author), Maosheng Cheng (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

AbstractAiming to address the insufficient endocytosis ability of traditional albumin drug conjugates, this paper reports elegant guanidine modification to improve efficacy for the first time. A series of modified albumin drug conjugates were designed and synthesized with different structures, inclu...