An early, reversible cholesterolgenic etiology of diet-induced insulin resistance

• Main Authors: Jacob D. Covert (Author), Brian A. Grice (Author), Matthew G. Thornburg (Author), Manpreet Kaur (Author), Andrew P. Ryan (Author), Lixuan Tackett (Author), Theja Bhamidipati (Author), Natalie D. Stull (Author), Teayoun Kim (Author), Kirk M. Habegger (Author), Donald A. McClain (Author), Joseph T. Brozinick (Author), Jeffrey S. Elmendorf (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A buildup of skeletal muscle plasma membrane (PM) cholesterol content in mice occurs within 1 week of a Western-style high-fat diet and causes insulin resistance. The mechanism driving this cholesterol accumulation and insulin resistance is not known. Promising cell data implicate that th...