Predicting the Effects of Carbapenem/Carbapenemase Inhibitor Combinations against KPC-Producing <i>Klebsiella pneumoniae</i> in Time-Kill Experiments: Alternative versus Traditional Approaches to MIC Determination

• Main Authors: Alla V. Filimonova (Author), Maria V. Golikova (Author), Elena N. Strukova (Author), Yury A. Portnoy (Author), Anastasiya A. Kuznetsova (Author), Stephen H. Zinner (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Traditionally, the antibacterial activity of β-lactam antibiotics in the presence of β-lactamase inhibitors is determined at the fixed inhibitor concentration. This traditional approach does not consider the ratio of antibiotic-to-inhibitor concentrations achieved in humans. To explore whether an al...