The NTCP p.Ser267Phe Variant Is Associated With a Faster Anti-HBV Effect on First-Line Nucleos(t)ide Analog Treatment

• Main Authors: Lina Wu (Author), Wenxiong Xu (Author), Xuejun Li (Author), Ying Liu (Author), Lu Wang (Author), Shu Zhu (Author), Fangji Yang (Author), Chan Xie (Author), Liang Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sodium taurocholate cotransporting polypeptide (NTCP) acts as a cellular receptor for the hepatitis B virus infection of host hepatocytes. Previously, many studies confirmed that the NTCP p.Ser267Phe variant was a protective factor against HBV-related disease progression. We therefore designed this...