Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss

• Main Authors: Maria Mavrikaki (Author), Clemence Girardet (Author), Andras Kern (Author), Alicia Faruzzi Brantley (Author), Courtney A. Miller (Author), Heather Macarthur (Author), Daniel L. Marks (Author), Andrew A. Butler (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Appetitive responses to weight loss are mediated by a nutrient-sensing neural network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors (MC3R) in mediating these responses is enigmatic. Mc3r knockout mice exhibit a paradoxical phenotype of obesity and reduced...