The Phenoxazine Derivative Phx-1 Suppresses IgE-Mediated Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells

• Main Authors: Eisuke Enoki (Author), Kiyonao Sada (Author), Xiujuan Qu (Author), Shinkou Kyo (Author), S.M. Shahjahan Miah (Author), Tomoko Hatani (Author), Akio Tomoda (Author), Hirohei Yamamura (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antigen-induced aggregation of the high affinity IgE receptor (FcεRI) on mast cells induces degranulation to release chemical mediators, leading to acute allergic inflammation. We have demonstrated that the treatment of rat mast cells, RBL-2H3, with a phenoxazine derivative Phx-1 (2-amino-4,4α-dihyd...