Myricanol rescues dexamethasone‐induced muscle dysfunction via a sirtuin 1‐dependent mechanism

• Main Authors: Shengnan Shen (Author), Qiwen Liao (Author), Jingxin Liu (Author), Ruile Pan (Author), Simon Ming‐Yuen Lee (Author), Ligen Lin (Author)
• Format: Book
• Published: Wiley, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscle atrophy and weakness are adverse effects of high dose or the sustained usage of glucocorticoids. Loss of mitochondria and degradation of protein are highly correlated with muscle dysfunction. The deacetylase sirtuin 1 (SIRT1) plays a vital role in muscle remodelling. The c...