A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation

• Main Authors: Simon W. F. Mok (Author), Wu Zeng (Author), Yuzhen Niu (Author), Paolo Coghi (Author), Yujun Wu (Author), Wai Man Sin (Author), Sio Ian Ng (Author), Flora Gordillo-Martínez (Author), Jia Yin Gao (Author), Betty Y. K. Law (Author), Liang Liu (Author), Xiaojun Yao (Author), Vincent K. W. Wong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine 5'-monophsphate-activated protein kinase (AMPK) is a crucial energy sensor for maintaining cellular homeostasis. Targeting AMPK may provide an alternative approach in treatment of various diseases like cancer, diabetes, and neurodegenerations. Accordingly, novel AMPK activators are fr...