Hydroxysafflor Yellow A Blocks HIF-1<i>α</i> Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium

• Main Authors: Yi Li (Author), Xiao-Tian Liu (Author), Pei-Lin Zhang (Author), Yu-Chen Li (Author), Meng-Ru Sun (Author), Yi-Tao Wang (Author), Sheng-Peng Wang (Author), Hua Yang (Author), Bao-Lin Liu (Author), Mei Wang (Author), Wen Gao (Author), Ping Li (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zonula occludens-1 (ZO-1) is a tight junction protein in the cerebrovascular endothelium, responsible for blood-brain barrier function. Hydroxysafflor yellow A (HSYA) is a major ingredient of safflower (<i>Carthamus tinctorius</i> L.) with antioxidative activity. This study investigated...