Optimization of Rifapentine-Loaded Lipid Nanoparticles Using a Quality-by-Design Strategy

• Ngā kaituhi matua: Joana Magalhães (Author), Luise L. Chaves (Author), Alexandre C. Vieira (Author), Susana G. Santos (Author), Marina Pinheiro (Author), Salette Reis (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2020-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

This work aims to optimize and assess the potential use of lipid nanoparticles, namely nanostructured lipid carriers (NLCs), as drug delivery systems of rifapentine (RPT) for the treatment of tuberculosis (TB). A Box−Behnken design was used to increase drug encapsulation efficiency (EE) and loading...