Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

• Main Authors: Hyunbae Kim (Author), Juncheng Wei (Author), Zhenfeng Song (Author), Emilio Mottillo (Author), Lobelia Samavati (Author), Ren Zhang (Author), Li Li (Author), Xuequn Chen (Author), Bhanu P. Jena (Author), Jiandie D. Lin (Author), Deyu Fang (Author), Kezhong Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery. Here, we investigated the molecular mechanism and functional significance underlying the circadian regulation of HRD1/Sel1L-mediated protei...