Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

• मुख्य लेखकों: Hyunbae Kim (लेखक), Juncheng Wei (लेखक), Zhenfeng Song (लेखक), Emilio Mottillo (लेखक), Lobelia Samavati (लेखक), Ren Zhang (लेखक), Li Li (लेखक), Xuequn Chen (लेखक), Bhanu P. Jena (लेखक), Jiandie D. Lin (लेखक), Deyu Fang (लेखक), Kezhong Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery. Here, we investigated the molecular mechanism and functional significance underlying the circadian regulation of HRD1/Sel1L-mediated protei...