Bacteroides Fragilis Polysaccharide A Ameliorates Abnormal Voriconazole Metabolism Accompanied With the Inhibition of TLR4/NF-κB Pathway

• Main Authors: Xiaokang Wang (Author), Chunxiao Ye (Author), Tianrong Xun (Author), Liqian Mo (Author), Yong Tong (Author), Wensi Ni (Author), Suping Huang (Author), Bin Liu (Author), Xia Zhan (Author), Xixiao Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The antifungal agent voriconazole (VRC) exhibits extreme inter-individual and intra-individual variation in terms of its clinical efficacy and toxicity. Inflammation, as reflected by C-reactive protein (CRP) concentrations, significantly affects the metabolic ratio and trough concentrations of voric...