Integrative multi-omics analysis depicts the methylome and hydroxymethylome in recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression

• Main Authors: Zhen-Duo Shi (Author), Xiao-Xiao Han (Author), Zi-Jian Song (Author), Yang Dong (Author), Kun Pang (Author), Xin-Lei Wang (Author), Xin-Yu Liu (Author), Hao Lu (Author), Guang-Zhi Xu (Author), Lin Hao (Author), Bing-Zheng Dong (Author), Qing Liang (Author), Xiao-Ke Wu (Author), Cong-Hui Han (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictions difficult. Epigenetic alterations, especially DNA methylation, play...