Case Report: Fatal Multiorgan Failure and Heterochronous Pneumonitis Following Pembrolizumab Treatment in a Patient With Large-Cell Neuroendocrine Carcinoma of Lung

• Main Authors: Xiaohong Xie (Author), Fei Wang (Author), Yinyin Qin (Author), Xinqing Lin (Author), Zhanhong Xie (Author), Ming Liu (Author), Ming Ouyang (Author), Bihui Luo (Author), Yingying Gu (Author), Shiyue Li (Author), Dejian Gu (Author), Rongrong Chen (Author), Chengzhi Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint inhibitors have radically changed the landscape of antitumor therapies in several malignancies. Despite the long-term efficacy, severe immune-related adverse events (irAEs) were not uncommon. However, fatal simultaneous multiorgan failure was rare. Here, we described a patient who...