Silencing of tropomodulin 1 inhibits acute myeloid leukemia cell proliferation and tumor growth by elevating karyopherin alpha 2-mediated autophagy

• Main Authors: Yuan Xia (Author), Dan Wang (Author), Huijie Zhao (Author), Tingyi Meng (Author), Qingling Jiang (Author), Zhaohai Pan (Author), Guoli Wang (Author), Tianyue An (Author), Bohan Li (Author), Sixue Bi (Author), Huikai Wang (Author), Jun Lu (Author), Hongfu Liu (Author), Haiyan Lin (Author), Chunhua Lin (Author), Qiusheng Zheng (Author), Defang Li (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evidence shows that tropomodulin 1 (TMOD1) is a powerful diagnostic marker in the progression of several cancer types. However, the regulatory mechanism of TMOD1 in tumor progression is still unclear. Here, we showed that TMOD1 was highly expressed in acute myeloid leukemia (AML) specimens, and TMOD...