Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

• Главные авторы: Jessica D. Panes (Автор), Pamela A. Godoy (Автор), Tiare Silva-Grecchi (Автор), María T. Celis (Автор), Oscar Ramirez-Molina (Автор), Javiera Gavilan (Автор), Carola Muñoz-Montecino (Автор), Patricio A. Castro (Автор), Gustavo Moraga-Cid (Автор), Gonzalo E. Yévenes (Автор), Leonardo Guzmán (Автор), Jeffrey L. Salisbury (Автор), Eugenia Trushina (Автор), Jorge Fuentealba (Автор)
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• Опубликовано: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Предметы: article
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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ are not well understood. We s...