Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

• Main Authors: Jessica D. Panes (Author), Pamela A. Godoy (Author), Tiare Silva-Grecchi (Author), María T. Celis (Author), Oscar Ramirez-Molina (Author), Javiera Gavilan (Author), Carola Muñoz-Montecino (Author), Patricio A. Castro (Author), Gustavo Moraga-Cid (Author), Gonzalo E. Yévenes (Author), Leonardo Guzmán (Author), Jeffrey L. Salisbury (Author), Eugenia Trushina (Author), Jorge Fuentealba (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ are not well understood. We s...