Predictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks

ABSTRACTSolutions of monoclonal antibodies (mAbs) can show increased viscosity at high concentration, which can be a disadvantage during protein purification, filling, and administration. The viscosity is determined by protein-protein-interactions, which are influenced by the antibody's sequenc...

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Main Authors: Jonathan Schmitt (Author), Abbas Razvi (Author), Christoph Grapentin (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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