Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (5a-5g). Initially, we examin...

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Main Authors: Mater H. Mahnashi (Author), Umer Rashid (Author), Hassan Hussain Almasoudi (Author), Mohammed H. Nahari (Author), Imran Ahmad (Author), Abdulkarim S. Binshaya (Author), Osama Abdulaziz (Author), Meshari A. Alsuwat (Author), Muhammad Saeed Jan (Author), Abdul Sadiq (Author)
Format: Book
Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
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3rd Floor Main Library

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