Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies

• Үндсэн зохиолчид: Mater H. Mahnashi (Зохиогч), Umer Rashid (Зохиогч), Hassan Hussain Almasoudi (Зохиогч), Mohammed H. Nahari (Зохиогч), Imran Ahmad (Зохиогч), Abdulkarim S. Binshaya (Зохиогч), Osama Abdulaziz (Зохиогч), Meshari A. Alsuwat (Зохиогч), Muhammad Saeed Jan (Зохиогч), Abdul Sadiq (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (5a-5g). Initially, we examin...