Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway

• Principais autores: Yun Yang (Autor), Feng Ren (Autor), Ziyin Tian (Autor), Wei Song (Autor), Binfeng Cheng (Autor), Zhiwei Feng (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background and Purpose: Although trastuzumab has shown considerable activity in the treatment of HER2-positive breast and gastric cancers, a significant proportion of patients do not respond to trastuzumab. Recent studies revealed that osthole, an active coumarin isolated from Cnidium monnieri (L.)...