IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin

• Glavni autori: Satoshi Horiba (Autor), Ryota Kami (Autor), Taiki Tsutsui (Autor), Junichi Hosoi (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2022-05-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Macrophages can be polarized into two subsets: a proinflammatory (M1) or an anti-inflammatory (M2) phenotype. In this study, we show that an increased M1-to-M2 ratio associated with a decrease in IL-34 induces skin inflammaging. The total number of macrophages in the dermis did not change, but the n...