Internalization of Constitutively Active N111G Mutant of AT1 Receptor Induced by Angiotensin II-Receptor Antagonists Candesartan, Losartan, and Telmisartan: Comparison With Valsartan

• Main Authors: Mohiuddin Ahmed Bhuiyan (Author), Murad Hossain (Author), Takashi Nakamura (Author), Masanobu Ozaki (Author), Takafumi Nagatomo (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on radioligand binding and signal transduction assays in our previous study, we have determined the binding pattern and functional efficacy of the constitutively active mutant N111G of angiotensin II type 1 (AT1) receptor. We have also shown that the N111G mutant induces homologous internaliza...