Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease

• Main Authors: Jun Mo (Author), Tingkai Chen (Author), Hongyu Yang (Author), Yan Guo (Author), Qi Li (Author), Yuting Qiao (Author), Hongzhi Lin (Author), Feng Feng (Author), Wenyuan Liu (Author), Yao Chen (Author), Zongliang Liu (Author), Haopeng Sun (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer's disease (AD). Herein, we report the medicinal chemistry efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives. Among the synthesised compounds, 15b and 15j showed submicromolar...