Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age

• Main Authors: Maria Goretti López-Ramos (Author), Joan Vinent (Author), Rob Aarnoutse (Author), Angela Colbers (Author), Eneritz Velasco-Arnaiz (Author), Loreto Martorell (Author), Lola Falcón-Neyra (Author), Olaf Neth (Author), Luis Prieto (Author), Sara Guillén (Author), Fernando Baquero-Artigao (Author), Ana Méndez-Echevarría (Author), David Gómez-Pastrana (Author), Ana Belén Jiménez (Author), Rebeca Lahoz (Author), José Tomás Ramos-Amador (Author), Antoni Soriano-Arandes (Author), Begoña Santiago (Author), Rosa Farré (Author), Clàudia Fortuny (Author), Dolors Soy (Author), Antoni Noguera-Julian (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In 2010, the WHO recommended an increase in the daily doses of first-line anti-tuberculosis medicines in children. We aim to characterize the pharmacokinetics of the once-daily isoniazid (INH) dose at 10 mg/kg of body weight in infants <6 months of age. We performed a multicenter pharmacokinetic...