Discordant immunohistochemistry in an unusual MLH1 gene variant in a case of Lynch syndrome

• Main Authors: Prerana Nagabhushana (Author), Snigdha Kumari (Author), Minakshi Rohilla (Author), Radhika Srinivasan (Author), Aashima Arora (Author), Pulkit Rastogi (Author)
• Format: Book
• Published: Elsevier, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunohistochemistry for mismatch repair proteins and microsatellite instability testing are recommended screening methods for Lynch syndrome. They have a good sensitivity and specificity, allowing for directed genetic testing and diagnosis. We report a case of Lynch syndrome with retained MMR prote...