Role of the ubiquitin-proteasome system in the sarcopenic-like phenotype induced by CCL5/RANTES

• Main Authors: Sabrina Conejeros-Lillo (Author), Francisco Aguirre (Author), Daniel Cabrera (Author), Felipe Simon (Author), Luis Peñailillo (Author), Claudio Cabello-Verrugio (Author)
• Format: Book
• Published: PAGEPress Publications, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ligases belonging to UPS, leading to proteolysi...