Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF^V600E

• Main Authors: Samar A. El-Kalyoubi (Author), Hesham A. M. Gomaa (Author), Elshimaa M. N. Abdelhafez (Author), Mohamed Ramadan (Author), Fatimah Agili (Author), Bahaa G. M. Youssif (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The investigation of novel EGFR and BRAF^V600E dual inhibitors is intended to serve as targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed and synthesized as EGFR/BRAF^V600E dual inhibitors. The majority of the compounds...