Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

• Main Authors: Zhao Yan (Author), Xiaoxi Tian (Author), Jinyu Zhu (Author), Zifan Lu (Author), Lifeng Yu (Author), Dawei Zhang (Author), Yanwu Liu (Author), Chongfei Yang (Author), Qingsheng Zhu (Author), Xiaorui Cao (Author)
• Format: Book
• Published: BMC, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanisms related to excessive bone resorption associated with osteolysis and t...