Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

• Hoofdauteurs: Zhao Yan (Auteur), Xiaoxi Tian (Auteur), Jinyu Zhu (Auteur), Zifan Lu (Auteur), Lifeng Yu (Auteur), Dawei Zhang (Auteur), Yanwu Liu (Auteur), Chongfei Yang (Auteur), Qingsheng Zhu (Auteur), Xiaorui Cao (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2018-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanisms related to excessive bone resorption associated with osteolysis and t...