A Synthetic Hydrogel, VitroGel® ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells

• Main Authors: Michelle D. Cherne (Author), Barkan Sidar (Author), T. Andrew Sebrell (Author), Humberto S. Sanchez (Author), Kody Heaton (Author), Francis J. Kassama (Author), Mandi M. Roe (Author), Andrew B. Gentry (Author), Connie B. Chang (Author), Seth T. Walk (Author), Mark Jutila (Author), James N. Wilking (Author), Diane Bimczok (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunosurveillance of the gastrointestinal epithelium by mononuclear phagocytes (MNPs) is essential for maintaining gut health. However, studying the complex interplay between the human gastrointestinal epithelium and MNPs such as dendritic cells (DCs) is difficult, since traditional cell culture sy...