Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood-brain barrier and interacts with amyloid β

• Main Authors: Rebecca Faresjö (Author), Elisabet O. Sjöström (Author), Tiffany Dallas (Author), Magnus M. Berglund (Author), Jonas Eriksson (Author), Dag Sehlin (Author), Stina Syvänen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurodegenerative diseases such as Alzheimer's disease (AD) pose substantial challenges to patients and health-care systems, particularly in countries with aging populations. Immunotherapies, including the marketed antibodies lecanemab (Leqembi®) and donanemab (KisunlaTM), offer promise but fac...