Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses

• Main Authors: Yousong Peng (Author), Wenfei Zhu (Author), Zhaomin Feng (Author), Zhaozhong Zhu (Author), Zheng Zhang (Author), Yongkun Chen (Author), Suli Liu (Author), Aiping Wu (Author), Dayan Wang (Author), Yuelong Shu (Author), Taijiao Jiang (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The virulence of influenza viruses is a complex multigenic trait. Previous studies about the virulence determinants of influenza viruses mainly focused on amino acid sites, ignoring the influence of nucleotide mutations. In this study, we collected >200 viral strains from 21 subtypes of influenza...