Stability of Naked Nucleic Acids under Physical Treatment and Powder Formation: Suitability for Development as Dry Powder Formulations for Inhalation

• Main Authors: Tomoyuki Okuda (Author), Maki Okazaki (Author), Akihiko Hayano (Author), Hirokazu Okamoto (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

A number of functional nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), have been attracting increasing attention as new therapeutic modalities worldwide. Dry pDNA and siRNA powder formulations for inhalation are considered practical in clinical applications for respira...