Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome

• Main Authors: Sergey V. Valiulin (Author), Andrei A. Onischuk (Author), Anatoly M. Baklanov (Author), Sergey V. An'kov (Author), Sergey N. Dubtsov (Author), Alexander A. Alekseev (Author), Nikolay N. Shkil (Author), Ekaterina V. Nefedova (Author), Maria E. Plokhotnichenko (Author), Tatyana G. Tolstikova (Author), Arseniy M. Dolgov (Author), Galina G. Dultseva (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5-1.5 μm and mass concentration 0.01-0.6 μg/cm³ was used in inhalation experiments. Pharmacokinetic measurements were carried out using a...