Tumor Necrosis Factor-α Mediates the Blood-Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells

• Main Authors: Tsuyoshi Nishioku (Author), Junichi Matsumoto (Author), Shinya Dohgu (Author), Noriko Sumi (Author), Kenji Miyao (Author), Fuyuko Takata (Author), Hideki Shuto (Author), Atsushi Yamauchi (Author), Yasufumi Kataoka (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was designed to elucidate the involvement of tumor necrosis factor-α (TNF-α) release from activated microglia in the induction of blood-brain barrier (BBB) dysfunction in an in vitro co-culture system with mouse brain capillary endothelial cells (MBEC4) and microglia. Lipopolysacch...